The Roma, Irena, was born in 1751 in Central Europe and suffered her first death in 1779, when she was hanged as a witch for predicting the future. Her mentor was Jacob Galati, another Immortal Roma. He taught her what she needed to know as an Immortal. Remi Vijayha, Jacob's watcher, observed Irena as well from 1840. Irena married Jacob Galati around the year 1844.
In 1847, Jacob and Irena's Roma group was in the vicinity of the Rhone, either in Switzerland or in France. The Immortal, Duncan MacLeod had joined Jacob and Irena's group, and they had become good friends. One day, a man from a nearby village lured Irena into a barn and raped her. Jacob wanted to kill him in retaliation, but MacLeod convinced him to surrender the man to local justice. The local judiciary however, had no love for gypsies and let the perpetrator go unpunished. When he boasted of his act, Jacob took his revenge on him. He was hanged for the murder and was, for their mortal friends, dead. Irena went on alone and when Jacob followed, they began a new life together. Remi Vijayha remained as their watcher, but Duncan MacLeod did not accompany the Galatis.
In 1992, Jacob and Irene lived in France. They had become sedentary and had a house, Irena worked as a dancer. When their house took fire, and they fled into the forest, they were surrounded by mortals. Their leader, James Horton knew of their immortality. He ordered his men to shoot the Galatis. When they revived Jacob was tied to a tree and despite her pleas for mercy, Horton beheaded Irena. Her Quickening was absorbed by Jacob who then managed to escape. Irena and Jacob's watcher, Maria Pezza, was later found near the burnt house with a broken neck. It is not known with certainty whether Horton or Jacob Galati killed Maria, but evidence suggests that James Horton was responsible.
Duncan MacLeod later recalled Irena as a sensitive woman with good people skills. She was not vengeful.