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She was the first long-time girlfriend of Duncan MacLeod after Tessa Noël's death, and was a trauma surgeon. She saw Duncan fall to his death, making him go to Paris to avoid telling her the truth. Later, he changed his mind, told her about his immortality and she went to France to stay with him. She got pregnant by a friend who stood by her while she was mourning Duncan's loss in Seacouver. The Highlander, however, decided to raise her child as his own kid. After seeing Duncan fight another Immortal, she decided to leave Duncan. According to her, she "saved lives" and could not live with so many deaths. She met Duncan some months later, in Seacouver, and he end up helping Anne through labor, when they were trapped in a subway station after an explosion. She gave birth to a baby girl, who she named after Duncan's mother, Mary. Duncan made a gift of the house he was renovating to Anne and her daughter.

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